Initial cellular target in multiple system atrophy: Glial cell
نویسندگان
چکیده
منابع مشابه
Multiple system atrophy: cellular and molecular pathology.
Multiple system atrophy is an adult onset neurodegenerative disease, featuring parkinsonism, ataxia, and autonomic failure, in any combination. The condition is relentlessly progressive and responds poorly to treatment. Death occurs on average six to seven years after the onset of symptoms. No familial cases of multiple system atrophy have been reported, and no environmental factors have been r...
متن کاملCellular pathology of multiple system atrophy: a review.
cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome). Metal-catalyzed oxidation renders silver intensifica-tion selective. Application for the histochemistry of diaminobenzidine and neurofibrillary changes. 6 Horoupian DS, Dickson DW. Striatonigral degeneration, olivopontocere-bellar atrophy...
متن کاملMultiple system atrophy.
Multiple system atrophy (MSA) is an adult-onset sporadic progressive neurodegenerative disorder of unknown etiology. It is clinically characterized by the variable combination of autonomic failure, parkinsonism, cerebellar ataxia, and pyramidal signs. The present review summarizes up-to-date knowledge on the clinical diagnosis and molecular pathology of MSA. We also review the role of additiona...
متن کاملMultiple system atrophy.
Multiple system atrophy is a neurological disorder that has gone unrecognized for too long due to its involvement across multiple regions of the central nervous system. This disorder is finally being unveiled through increased reporting in the scientific literature. Further research will enhance our understanding of this disease and lead to more effective treatment regimens as well as an improv...
متن کاملDystonia in multiple system atrophy.
OBJECTIVE To delineate the frequency and nature of dystonia in multiple system atrophy (MSA). METHODS A cohort of 24 patients with clinically probable MSA over the past 10 years were prospectively followed up. Motor features were either dominated by parkinsonism (MSA-P subtype, n=18) or cerebellar ataxia (MSA-C, n=6). Classification of dystonic features and their changes with time was based o...
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ژورنال
عنوان ژورنال: Rinsho Shinkeigaku
سال: 2011
ISSN: 0009-918X,1882-0654
DOI: 10.5692/clinicalneurol.51.843